FROM BIOINFORMATICS TO CLINICAL APPLICATIONS: A NOVEL PROGNOSTIC MODEL OF CUPROPTOSIS-RELATED GENES BASED ON SINGLE-CELL RNA SEQUENCING DATA IN HEPATOCELLULAR CARCINOMA

Abstract Objective and methods To ascertain the connection between cuproptosis-related genes (CRGs) and the prognosis of hepatocellular carcinoma (HCC) via single-cell RNA two tone woven basket sequencing (scRNA-seq) and RNA sequencing (RNA-seq) data, relevant data were downloaded from the GEO and TCGA databases.The differentially expressed CRGs (D

ludwig modular hardware The aim of this paper is to examine the effect of CEO duality, women directors and BIG 4 audit firm on real earnings manipulation (REM) proxied by cash flow from operation and discretionary expenses (DE).The sample of the study was Malaysian Public Listed Companies in year 2009-2012 with a sample of 1597 firm-year observatio

Influenza A virus causes annual epidemics and occasional pandemics of short-term respiratory infections associated with considerable morbidity and mortality.The pandemics occur when new human-transmissible viruses that have the major surface protein of influenza A viruses from other host species are introduced into the human population.Between such

Concern about zoonoses and wildlife has increased.Few studies described the role of wild mammals and environments in the epidemiology of Salmonella.Antimicrobial resistance is a growing problem associated with Salmonella that threatens global health, food security, the economy, and development in the 21st century.The aim of this study nova upright